Psychedelics for Treating Mental Disorders | Dr. Matthew Johnson
In this episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We explore the biology and medical clinical trial uses of psilocybin, MDMA, ayahuasca, DMT and LSD.
Dr. Johnson shares what the clinical trials in his lab reveal about the potential these compounds hold for treating depression, addiction, trauma, eating disorders, ADHD and other disorders of the mind. He describes a typical psychedelic experiment in his laboratory from start to finish, including the conditions that support optimal clinical outcomes. He also outlines potential hazards along with common misconceptions and pitfalls related to psychedelic medicine.
Dr. Johnson explains flashbacks, the heightened risks certain people and age groups face when using psychedelics, and the ever-evolving legal and pharmaceutical landscape surrounding these substances. He discusses how the scientific study of psychedelics is likely to shape the future trajectory of psychiatric medicine.
As one of a small handful of researchers who have pioneered the clinical study of these powerful compounds, Dr. Johnson offers unprecedented insight into how they can be woven into other psychiatric treatments, changing one’s sense of self and reality.
For an up-to-date list of our current sponsors, please visit our website: https://www.hubermanlab.com/sponsors. Previous sponsors mentioned in this podcast episode may no longer be affiliated with us.
Dr. Matthew Johnson Social Media:
Twitter: https://twitter.com/Drug_Researcher
Instagram: https://www.instagram.com/drug_researcher
Social:
Instagram - https://www.instagram.com/hubermanlab
Twitter - https://twitter.com/hubermanlab
Facebook - https://www.facebook.com/hubermanlab
Website - https://hubermanlab.com
Newsletter - https://hubermanlab.com/neural-network
Links:
Dr. Johnson’s Website at Johns Hopkins School of Medicine - https://hopkinspsychedelic.org/johnson
Chris Letheby’s forthcoming book - https://amzn.to/3nMTaAs
Timestamps:
00:00:00 Introducing Dr. Matthew Johnson
00:02:10 Supporting Sponsors
00:06:40 ‘Psychedelics’ Defined
00:14:09 Hallucinations, Synesthesia, Altered Space-Time Perception
00:19:56 Serotonin & Dopamine
00:23:50 Ketamine & Glutamate
00:28:00 An Example Psychedelic Experiment
00:37:30 ‘Letting Go’ with Psychedelics
00:44:10 Our Mind’s Eye
00:48:00 Redefining Your Sense of Self
00:58:56 Exporting Psychedelic Learnings to Daily Life
01:04:36 Flashbacks
01:12:10 Ayahuasca, & ASMR, Kundalini Breathing
01:15:54 MDMA, DMT
01:26:00 Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis
01:38:15 Micro-Dosing
01:56:45 Risks for Kids, Adolescents & Teenagers; Future Clinical Trials
02:03:40 Legal Status: Decriminalization vs. Legalization vs. Regulation
02:18:35 Psychedelics for Treating Concussion & Traumatic Brain Injury
02:27:45 Shifting Trends in Psychedelic Research, Academic Culture
02:44:23 Participating in a Clinical Trial, Online Survey Studies, Breathwork
02:50:38 Conclusions, Subscribing & Supporting the HLP, Supplements
Please note that The Huberman Lab Podcast is distinct from Dr. Huberman's teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
In this episode I discuss medical research on psychedelic compounds with Dr. Matthew Johnson, Professor of Psychiatry and Behavioral Sciences at Johns Hopkins School of Medicine. We explore the biology and medical clinical trial uses of psilocybin, MDMA, ayahuasca, DMT and LSD.
Dr. Johnson shares what the clinical trials in his lab reveal about the potential these compounds hold for treating depression, addiction, trauma, eating disorders, ADHD and other disorders of the mind. He describes a typical psychedelic experiment in his laboratory from start to finish, including the conditions that support optimal clinical outcomes. He also outlines potential hazards along with common misconceptions and pitfalls related to psychedelic medicine.
Dr. Johnson explains flashbacks, the heightened risks certain people and age groups face when using psychedelics, and the ever-evolving legal and pharmaceutical landscape surrounding these substances. He discusses how the scientific study of psychedelics is likely to shape the future trajectory of psychiatric medicine.
As one of a small handful of researchers who have pioneered the clinical study of these powerful compounds, Dr. Johnson offers unprecedented insight into how they can be woven into other psychiatric treatments, changing one’s sense of self and reality.
For an up-to-date list of our current sponsors, please visit our website: https://www.hubermanlab.com/sponsors. Previous sponsors mentioned in this podcast episode may no longer be affiliated with us.
Dr. Matthew Johnson Social Media:
Twitter: https://twitter.com/Drug_Researcher
Instagram: https://www.instagram.com/drug_researcher
Social:
Instagram – https://www.instagram.com/hubermanlab
Twitter – https://twitter.com/hubermanlab
Facebook – https://www.facebook.com/hubermanlab
Website – https://hubermanlab.com
Newsletter – https://hubermanlab.com/neural-network
Links:
Dr. Johnson’s Website at Johns Hopkins School of Medicine – https://hopkinspsychedelic.org/johnson
Chris Letheby’s forthcoming book – https://amzn.to/3nMTaAs
Timestamps:
00:00:00 Introducing Dr. Matthew Johnson
00:02:10 Supporting Sponsors
00:06:40 ‘Psychedelics’ Defined
00:14:09 Hallucinations, Synesthesia, Altered Space-Time Perception
00:19:56 Serotonin & Dopamine
00:23:50 Ketamine & Glutamate
00:28:00 An Example Psychedelic Experiment
00:37:30 ‘Letting Go’ with Psychedelics
00:44:10 Our Mind’s Eye
00:48:00 Redefining Your Sense of Self
00:58:56 Exporting Psychedelic Learnings to Daily Life
01:04:36 Flashbacks
01:12:10 Ayahuasca, & ASMR, Kundalini Breathing
01:15:54 MDMA, DMT
01:26:00 Dangers of Psychedelics, Bad Trips, Long-Lasting Psychosis
01:38:15 Micro-Dosing
01:56:45 Risks for Kids, Adolescents & Teenagers; Future Clinical Trials
02:03:40 Legal Status: Decriminalization vs. Legalization vs. Regulation
02:18:35 Psychedelics for Treating Concussion & Traumatic Brain Injury
02:27:45 Shifting Trends in Psychedelic Research, Academic Culture
02:44:23 Participating in a Clinical Trial, Online Survey Studies, Breathwork
02:50:38 Conclusions, Subscribing & Supporting the HLP, Supplements
Please note that The Huberman Lab Podcast is distinct from Dr. Huberman’s teaching and research roles at Stanford University School of Medicine. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Huberman Lab Podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
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Amazing conversation! Two world-class scientists. Two world-class beards.
Baby I think I found it
With 613k views
Here we go
Be careful who you mess with when you're out and about, you never know who's gonna have the skills to kick your ass. LOL!
In which kind of severe illnesses does play Depersonalization/ Derealization Disorder… can people with that use mdma or psylocybin
Thank you! Amazing discussion, really excited about what the future of all this research brings!
"Letting go" refers to the process of releasing attachments, whether they are emotional, physical, or mental, to things or experiences that no longer serve you. It involves accepting change and allowing yourself to move forward without being hindered by past events or feelings.
I think this is a real shot in the foot by the therapy community; because "letting go" is not what you are doing. "Detaching" seems to me a better term. I fear is in how people interpret it, and how they may come with prior expectations. I imagine there may be people out there who'll try to prepare by reading up on what they "should do"! As if a trip can be prepared for in this way.
Salvinorin A is a fascinating one. What is it? What's it related to and how does it work?
“I am” is what God told the Israelites to call Him
It’s crazy that psilocybin meets virtually none of the Schedule I criteria but remains illegal. Meanwhile, alcohol meets all of the Schedule I criteria and is sold in the grocery store.
I can't believe that you made the most exciting topic in the world, i.e., psychedelics apear boring, Sad
I practice toltec shamanism. Toltec translates to artists. The art I create is the story of my life. Toltec deals with psychedelic medicine. The same DNA markers a schizophrenic and people with bipolar disorders are the same as a shamans DNA markers. I know I can help those children and adults with a spiritual crisis. i also am working my butt off to be a psychedelic therapist. Hopefully, I can volunteer somewhere as a shaman in psychedelic therapy.
Your advertisement is so annoying
Skip to 6:40 you’re welcome
Why does Andrew waffle so much and interrupt his guest? Who is the expert here? It’s clearly not Andrew based on this interview and lucky the other guy is so patient with Andrew and his ego…
great conversation ❤
Sometimes the bad trips are more profound than the "good" ones. It's much like lifting weights. Pushing yourself for another rep even when you don't think you physically can. With bad trips and the correct mindset, it's proving to your "self" that you can get through scary and often terrifying thoughts. Then days afterward you can reflect on what you have accomplished mentally. Completely gratifying, if you ask me? It illustrates the true power of one's soul or their self.
I was diagnosed with Depression as well as ADHD many years ago. I was prescribed Venlafaxine for the D and Methylphenidate for the ADHD. The Venlafaxine did nothing for me. I was introduced to psychedelics mushroom from mycotask for threatment of my depression. I tried a mild/medium dose of psilocybin, it was for recreational trailer purpose but I noticed for a few weeks after the experience, that I felt overall better mentally speaking, I felt happier, more in control of my feelings, social anxiety was gone etc. All from 1 experience!